Biome Cholesterol™ Probiotic:

• Helps support healthy cholesterol levels in healthy adults

Shelf-stable; refrigeration not required

No added:

GMOs | wheat | gluten | dairy | lactose | fructose | yeast | nuts | seeds | peanut | soy | egg | fish | shellfish | animal derivatives 

Gluten and dairy free

No artificial colours, flavours, sweeteners, or preservatives. 

Suitable for vegetarians and vegans

Adults: take 1 capsule daily alongside a meal, or as directed by your health practitioner. 

Warnings: Do not use if carton seal is missing or damaged, or if blister seal is broken.

Specific gut microorganisms have been shown to be able to modify our cholesterol levels via two key mechanisms: producing bile salt hydrolase (BSH) enzymes, and binding to cholesterol to help excrete it from the body (1). BSH enzymes help to reduce the reabsorption of bile salts from the digestive tract, increasing their excretion through the faeces. As they are made up of mostly cholesterol, it increases the excretion of cholesterol out of the body. The liver needs cholesterol to produce a range of important biological molecules, including hormones and more bile salts, so it is forced to pull cholesterol out of the blood to replace what was lost (2). Therefore, having a gut microbiota with a higher proportion of BSH-producing microorganisms may make it easier for some individuals to keep their blood cholesterol levels under control. Cholesterol can also adhere to the cellular surface of some gut microorganisms, so when these microorganisms are on their way out of the body (through faeces), they take more cholesterol with them (1). These observations indicate that supporting the gut microbiota with specific gut microorganisms may help to support healthy cholesterol levels. Research has shown that when a specific combination of three probiotic microorganisms found in Biome Cholesterol™ Probiotic are administered together, they can help to significantly improve the management of healthy cholesterol levels (1-4) via the two mechanisms discussed earlier (1). It is important to note that not all probiotic strains possess the ability to produce BSH enzymes or bind cholesterol to their cell walls, and these strains were carefully selected because of their ability to perform these functions well.

References

1. Bosch, M. et al. Lactobacillus plantarum CECT 7527, 7528 and 7529: Probiotic candidates to reduce cholesterol levels. J. Sci. Food Agric. 94, 803–809 (2014).

2. Padro, T., Santisteban, V., Huedo, P., Puntes, M., Aguiló, M., Espadaler-Mazo, J., & Badimon, L. (2024). Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans. Cardiovascular Research, 00, 1–15.

3. ​​Fuentes, M. C., Lajo, T., Carrión, J. M., & Cuñé, J. (2016). A randomized clinical trial evaluating a proprietary mixture of Lactobacillus plantarum strains for lowering cholesterol. Mediterranean Journal of Nutrition and Metabolism, 9(2), 125-135.

4. Espadaler, J., Audivert, S., Navarro-Tapia, E., & Buj, D. (2019). Demographic and clinical characteristics influencing the effects of a cholesterol lowering probiotic. Annals of Nutrition & Metabolism, 74(S1), 6.